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3-甲基丁炔醇-3

3-甲基丁炔醇-3用途

【用途一】
用作合成医药、农药、萜烯类香料的中间体，酸蚀抑制剂、粘度稳定剂、减粘剂等

3-甲基丁炔醇-3名称

[ CAS 号 ]:
115-19-5

[ 中文名 ]:
2-甲基-3-丁炔-2-醇

[ 英文名 ]:
3-Methyl butynol

[中文别名 ]:

[英文别名 ]:

2-methylbut-3-yn-2-ol
3-Methyl butynol
3-Methyl-1-butyn-3-ol
2-Methyl-3-butyn-2-ol
3-Butyn-2-ol, 2-methyl-
MFCD00004467
EINECS 204-070-5

3-甲基丁炔醇-3物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
104.2±8.0 °C at 760 mmHg

[ 熔点 ]:
3 °C

[ 分子式 ]:
C₅H₈O

[ 分子量 ]:
84.116

[ 闪点 ]:
25.0±0.0 °C

[ 精确质量 ]:
84.057518

[ PSA ]:
20.23000

[ LogP ]:
0.32

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
17.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.444

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
miscible

3-甲基丁炔醇-3MSDS

3-甲基丁炔醇-3毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES0810000

CHEMICAL NAME :: 3-Butyn-2-ol, 2-methyl-

CAS REGISTRY NUMBER :: 115-19-5

BEILSTEIN REFERENCE NO. :: 0635746

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H8-O

MOLECULAR WEIGHT :: 84.13

WISWESSER LINE NOTATION :: QX1&1&1UU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,230,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(4),55,1987

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/m3

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(4),55,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1161 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,181,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1058 No. of Facilities: 67 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 3234 (estimated) No. of Female Employees: 2672 (estimated)

3-甲基丁炔醇-3安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R22;R41

[ 安全声明 (欧洲) ]:
S26-S39-S16

[ 危险品运输编码 ]:
UN 1987 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
ES0810000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
29052990

3-甲基丁炔醇-3合成路线

3-甲基丁炔醇-3上下游产品

3-甲基丁炔醇-3上游产品

3-甲基丁炔醇-3下游产品

3-甲基丁炔醇-3制备

1.制法：

于装有搅拌器、滴液漏斗、回流冷凝器(氨干燥管)、通气导管的反应瓶中，加入无水乙醚1L，研的很细的氨基钠156g（4mol），冰盐浴冷却下慢慢滴加无水丙酮(2)232g(4mol),约3h加完。冷至-10℃，慢慢通入乙炔气流2h以赶出氨。将进气管的一端深入瓶底，另一端与乙炔气体钢瓶相连，塞子用金属丝缚牢，冰盐浴冷却并将整个装置置于振动器上，剧烈摇动下反应10h(保持在0.7MPa乙炔压力下)。每30min打开活塞解除压力一次以除去氨。反应结束后，将反应物慢慢倒入800g碎冰中，冷却下加入20mol/L的硫酸400mL进行酸化。分出有机层，水层用乙醚提取2次。合并乙醚层，无水碳酸钾干燥。过滤，回收溶剂后分馏，收集103～107℃的馏分，得无色液体化合物(1)135～155g,收率46%。

3-甲基丁炔醇-3海关

[ 海关编码 ]: 29052990