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1-甲基-1-环己甲酸

1-甲基-1-环己甲酸用途

用作有机合成试剂。

1-甲基-1-环己甲酸名称

[ CAS 号 ]:
1123-25-7

[ 中文名 ]:
1-甲基环己烷羧酸

[ 英文名 ]:
1-Methylcyclohexanecarboxylic acid

[中文别名 ]:

[英文别名 ]:

EINECS 214-371-3
1-Methylcyclohexanecarboxylic acid
Cyclohexanecarboxylic acid, 1-methyl-
1-methylcyclohexane-1-carboxylic acid
MFCD00001463

1-甲基-1-环己甲酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
234.0±0.0 °C at 760 mmHg

[ 熔点 ]:
36-39 °C(lit.)

[ 分子式 ]:
C₈H₁₄O₂

[ 分子量 ]:
142.196

[ 闪点 ]:
100.6±0.0 °C

[ 精确质量 ]:
142.099380

[ PSA ]:
37.30000

[ LogP ]:
2.32

[ 外观性状 ]:
白色类白色晶体-粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.472

[ 储存条件 ]:
室温，干燥

1-甲基-1-环己甲酸MSDS

1-甲基-1-环己甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU8585500

CHEMICAL NAME :: Cyclohexanecarboxylic acid, 1-methyl-

CAS REGISTRY NUMBER :: 1123-25-7

BEILSTEIN REFERENCE NO. :: 1859220

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H14-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985

1-甲基-1-环己甲酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GU8585500

[ 海关编码 ]:
2916209090

1-甲基-1-环己甲酸合成路线

1-甲基-1-环己甲酸制备

在冰醋酸中以氧化铂为催化剂将邻甲基苯甲酸氢化还原可制得反式异构体。在氢氧化钠溶液中以兰尼镍(Raney Ni)为催化剂时得顺式异构体。

1-甲基-1-环己甲酸海关

[ 海关编码 ]: 2916209090

[ 中文概述 ]:
2916209090 其他（环烷、环烯、环萜烯）一元羧酸（包括酸酐、酰卤化物，过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

1-甲基-1-环己甲酸文献

Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid.

J. Pharmacol. Exp. Ther. 283(2) , 698-703, (1997)

Cytochrome P450-dependent desaturation of the anticonvulsant drug valproic acid (VPA) results in formation of the hepatotoxin, 4-ene-VPA. Polytherapy with other anticonvulsants which are known P450 in...

Induction of neutrophilic differentiation of human promyelocytic leukemic cells by branched-chain carboxylic acid anticonvulsant drugs.

J. Biol. Response Mod. 3(2) , 132-7, (1984)

The anticonvulsant drug 1-methyl-1-cyclohexanecarboxylic acid ( MCCA ) has been shown to cause maturation of murine neuroblastoma cells in vitro at concentrations that are pharmacologically achievable...

Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid.

Biopharm. Drug Dispos. 14(4) , 325-39, (1993)

The pharmacokinetics of valproic acid (VPA) and three structural analogs, octanoic acid (OA), cyclohexanecarboxylic acid (CCA), and 1-methyl-1-cyclohexanecarboxylic acid (MCCA), were examined in femal...

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