烯酰吗啉

烯酰吗啉用途

二甲吗啉是一种吗啉类杀菌剂,可抑制真菌细胞壁的形成。二甲吗啉抑制卵霉菌P.citrophthora、P.parasitica、P.capsici和P.infestans的菌丝生长(EC50s分别为0.14µg/mL、0.38µg/mL、<0.1µg/mL和0.16-0.3µg/mL),但在体外对绿藻种C.vulgaris或S.obliquus的活性较弱(EC50s分别为47.46µg/mL和44.87µg/mL)。在MDA-kb2人类乳腺癌细胞的报告分析中,二甲基吗啉抑制雄激素受体(AR)活性,但在酵母抗雄激素筛选中不抑制(IC20s分别为0.263µM和38.5µM)。

烯酰吗啉名称

[ CAS 号 ]:
110488-70-5

[ 中文名 ]:
烯酰吗啉

[ 英文名 ]:
dimethomorph

[中文别名 ]:

[英文别名 ]:

ACROBAT
MFCD01632781
Dimethoroph
CME 151
Akrobat
Forum
dimethomoph
EINECS 404-200-2
Festival C
Z-DIMETHOMORPH

烯酰吗啉生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

信号通路 >> 其他 >> 雄激素受体

烯酰吗啉物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
584.9±50.0 °C at 760 mmHg

[ 熔点 ]:
125-149ºC

[ 分子式 ]:
C₂₁H₂₂ClNO₄

[ 分子量 ]:
387.857

[ 闪点 ]:
307.5±30.1 °C

[ 精确质量 ]:
387.123749

[ PSA ]:
48.00000

[ LogP ]:
3.71

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
0-6°C

烯酰吗啉MSDS

详细MSDS(安全技术说明书)

烯酰吗啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE0478300

CHEMICAL NAME :: Morpholine, 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2 -propenyl)-

CAS REGISTRY NUMBER :: 110488-70-5

LAST UPDATED :: 199204

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H22-Cl-N-O4

MOLECULAR WEIGHT :: 387.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >4200 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

烯酰吗啉安全信息

[ 符号 ]:

GHS09

[ 危害声明 ]:
H411

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R51/53

[ 安全声明 (欧洲) ]:
S61

[ 危险品运输编码 ]:
UN3077 9/PG 3

[ RTECS号 ]:
QE0478300

[ 包装等级 ]:
III

烯酰吗啉文献

A molecularly imprinted polymer for the selective solid-phase extraction of dimethomorph from ginseng samples.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 182-186, (2015)

A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract dimethomorph from ginseng samples. Dimethomorph molecularly imprinted polymers with template to monomer molar...

Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens.

Environ. Health Perspect. 119 , 794-800, (2011)

Evidence suggests that there is widespread decline in male reproductive health and that antiandrogenic pollutants may play a significant role. There is also a clear disparity between pesticide exposur...

Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides.

Environ. Health Perspect. 120 , 1578-84, (2012)

Many pesticides in current use have recently been revealed as in vitro androgen receptor (AR) antagonists, but information about their combined effects is lacking.We investigated the combined effects ...

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