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Ω-芋螺毒素

Ω-芋螺毒素用途

ω-Conotoxin GVIA 是一种 N 型钙通道 (Ca2+ channel) 抑制剂。

Ω-芋螺毒素名称

[ CAS 号 ]:
106375-28-4

[ 中文名 ]:
Ω-芋螺毒素

[ 英文名 ]:
ω-Conotoxin GVIA trifluoroacetate salt

[中文别名 ]:

OMEGA-芋螺毒素GVIA

[英文别名 ]:

w-ConotoxinGVIA
w-Conotoxin GVIA,Conus geographus
o-Conotoxin GVIA
MFCD00076620
M.W. 3037.35 C120H182N38O43S6

Ω-芋螺毒素生物活性

[ 描述 ]:

ω-Conotoxin GVIA 是一种 N 型钙通道 (Ca2+ channel) 抑制剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 神经疾病

[体外研究]

ω-芋螺毒素GVIA(50nm,50nl)抑制尾加压素II(UII)的作用[1]。

[参考文献]

[1]. Ya-Kun Cao, et al. Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14/ERK pathway in rats. Hypertens Res. 2020 Aug;43(8):765-771.

Ω-芋螺毒素物理化学性质

[ 密度 ]:
1.71

[ 分子式 ]:
C₁₂₀H₁₈₂N₃₈O₄₃S₆

[ 分子量 ]:
3037.35000

[ 精确质量 ]:
3035.15000

[ PSA ]:
1496.38000

[ 储存条件 ]:
−20°C

Ω-芋螺毒素MSDS

详细MSDS(安全技术说明书)

Ω-芋螺毒素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
UN 3172

[ WGK德国 ]:
3

[ RTECS号 ]:
GL2665050

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

Ω-芋螺毒素文献

Differential blockade of rat alpha3beta4 and alpha7 neuronal nicotinic receptors by omega-conotoxin MVIIC, omega-conotoxin GVIA and diltiazem.

Br. J. Pharmacol. 127 , 1375, (1999)

Rat alpha3beta4 or alpha7 neuronal nicotinic acetylcholine receptors (AChRs) were expressed in Xenopus laevis oocytes, and the effects of various toxins and non-toxin Ca2+ channel blockers studied. Ni...

Spermine does not compete with omega-conotoxin GVIA in the striatum radiatum of the hippocampal slice.

Brain Res. 772 , 191, (1997)

The effect of spermine (Spm) and of omega-conotoxin GVIA (CTX) on the population excitatory postsynaptic potentials (pEPSP) in stratum radiatum of the CA1 area were compared. CTX decreased irreversibl...

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