地伐西匹
地伐西匹用途
地伐西匹名称
[ CAS 号 ]:
103420-77-5
[ 中文名 ]:
地伐西匹
[ 英文名 ]:
Devazepide
[英文别名 ]:
- Devazepida
- DEVAZEPIDE
- Devazepidum
- MK-329
地伐西匹生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
IC50: 45 pM (Rat pancreatic CCK receptor), 81 pM (Bovine gallbladder CCK receptor), 245 nM (Guinea pig brain CCK receptor)[1]
[参考文献]
地伐西匹物理化学性质
[ 密度 ]:
1.31g/cm3
[ 沸点 ]:
758.6ºC at 760mmHg
[ 分子式 ]:
C25H20N4O2
[ 分子量 ]:
408.45200
[ 闪点 ]:
412.6ºC
[ 精确质量 ]:
408.15900
[ PSA ]:
77.56000
[ LogP ]:
3.62930
[ 外观性状 ]:
白色至类白色粉末
[ 蒸汽压 ]:
6.56E-23mmHg at 25°C
[ 折射率 ]:
1.696
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱类、食品添加剂分开存放
地伐西匹MSDS
地伐西匹毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NL5994460
- CHEMICAL NAME :
- 1H-Indole-2-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodi azepin-3-yl)-, (S)-
- CAS REGISTRY NUMBER :
- 103420-77-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C25-H20-N4-O2
- MOLECULAR WEIGHT :
- 408.49
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,862,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,862,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,862,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,862,1989
地伐西匹安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H300
[ 警示性声明 ]:
P264-P301 + P310
[ 危害码 (欧洲) ]:
T
[ 安全声明 (欧洲) ]:
28-36/37-45
[ 危险品运输编码 ]:
UN 2811 6.1 / PGI
[ RTECS号 ]:
NL5994460
地伐西匹文献
Am. J. Physiol. Regul. Integr. Comp. Physiol. 301(5) , R1557-68, (2011)
The discovery that cells in the gastrointestinal (GI) tract express the same molecular receptors and intracellular signaling components known to be involved in taste has generated great interest in po...
Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety.Behav. Brain Res. 237 , 325-32, (2013)
This study investigated the roles of cholecystokinin (CCK)(A) and CCK(B) receptors on CCK-4-induced anxiety-like behaviors in mice through behavioral and neural evaluations. Anxiety-like behaviors in ...
Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice.BMC Neurosci. 9 , 101, (2008)
CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin (CCK) are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of l...
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相关化合物
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标题:地伐西匹_MSDS_用途_密度_地伐西匹CAS号【103420-77-5】_化源网 地址:https://www.chemsrc.com/amp/cas/103420-77-5_1104897.html