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3,4-二羟基苯乙酸

3,4-二羟基苯乙酸用途

3,4-Dihydroxybenzeneacetic acid 是多巴胺主要的代谢物。

3,4-二羟基苯乙酸名称

[ CAS 号 ]:
102-32-9

[ 中文名 ]:
3,4-二羟基苯乙酸

[ 英文名 ]:
3,4-Dihydroxyphenylacetic acid

[中文别名 ]:

高原儿茶酸

[英文别名 ]:

Benzeneacetic acid, 3,4-dihydroxy-
DOPAC
Benzeneacetic acid,3,4-dihydroxy
3,4-dihydroxy-1-benzeneacetic acid
3,4-dihydroxyphenylacetic acid
(3,4-dihydroxyphenyl)-Acetic acid
Homoprotocatechuic acid
4-Carboxymethylpyrocatechol
3,4-dihydroxyphenyl acetic acid
Pyrocatechol-4-acetic Acid

3,4-二羟基苯乙酸生物活性

[ 描述 ]:

3,4-Dihydroxybenzeneacetic acid 是多巴胺主要的代谢物。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

3,4-二羟基苯乙酸是多巴胺的主要神经元代谢产物。脑脊液(CSF)3,4-二羟基苯乙酸(DOPAC)来源于细胞质多巴胺的神经元内代谢,是中枢多巴胺缺乏的敏感和特异性生物标志物[1]。

[参考文献]

[1]. Goldstein DS, et al. Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies. Parkinsonism Relat Disord. 2016 Oct;31:79-86.

[相关活性小分子]

3,4-二羟基苯乙酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
418.4±30.0 °C at 760 mmHg

[ 熔点 ]:
127-130 °C(lit.)

[ 分子式 ]:
C₈H₈O₄

[ 分子量 ]:
168.147

[ 闪点 ]:
221.0±21.1 °C

[ 精确质量 ]:
168.042252

[ PSA ]:
77.76000

[ LogP ]:
0.17

[ 外观性状 ]:
米色粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.643

[ 储存条件 ]:
−20°C

3,4-二羟基苯乙酸MSDS

3,4-二羟基苯乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH0590000

CHEMICAL NAME :: Acetic acid, (3,4-dihydroxyphenyl)-

CAS REGISTRY NUMBER :: 102-32-9

BEILSTEIN REFERENCE NO. :: 2211017

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H8-O4

MOLECULAR WEIGHT :: 168.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981

3,4-二羟基苯乙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AH0590000

[ 海关编码 ]:
2918290000

3,4-二羟基苯乙酸合成路线

3,4-二羟基苯乙酸上下游产品

3,4-二羟基苯乙酸上游产品

3,4-二羟基苯乙酸下游产品

3,4-二羟基苯乙酸制备

1. 烟草：BU，26。

3,4-二羟基苯乙酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

3,4-二羟基苯乙酸文献

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PLoS ONE 10 , e0133904, (2015)

Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from per...

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.

J. Pharmacol. Exp. Ther. 350(3) , 589-604, (2014)

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for ser...

Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin.

J. Neurotrauma 32 , 1190-9, (2015)

Exposure to improvised explosive devices can result in a unique form of traumatic brain injury--blast-induced traumatic brain injury (bTBI). At the mild end of the spectrum (mild bTBI [mbTBI]), there ...

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