2,3'-脱水胸苷

更新时间：2025-08-27 08:25:38

2,3'-脱水胸苷结构式	常用名	2,3'-脱水胸苷	英文名	2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-
	CAS号	15981-92-7	分子量	224.21
	密度	1.72g/cm3	沸点	381.8ºC at 760mmHg
	分子式	C₁₀H₁₂N₂O₄	熔点	246-247ºC
	MSDS	美版	闪点	184.7ºC

2,3'-脱水胸苷用途

2,3'-无水硫脒；2'-脱氧-3',2-氢-5-甲基尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

中文名	2,3’-脱水胸苷
英文名	2,3'-anhydrothymidine
中文别名	2,3'-脱水胸苷
英文别名	更多

描述	2,3'-无水硫脒；2'-脱氧-3',2-氢-5-甲基尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
参考文献	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

密度	1.72g/cm3
沸点	381.8ºC at 760mmHg
熔点	246-247ºC
分子式	C₁₀H₁₂N₂O₄
分子量	224.21
闪点	184.7ºC
精确质量	208.08500
PSA	64.35000
InChIKey	JCSNHEYOIASGKU-UHFFFAOYSA-N
SMILES	Cc1cn2c(nc1=O)OC1CC2OC1CO
外观性状	白色粉末
蒸汽压	2.12E-07mmHg at 25°C
折射率	1.735

2,3'-脱水胸苷MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

[3'-(Tetrazol-2''-yl-3'-deoxythymidine and its 5''-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2''-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases].

Bioorg. Khim. 21 , 49-54, (1995)

5''-Derivatives of 3'-(tetrazole-2''-yl)-3'-deoxythymidines were synthesized by interaction of 5'-benzoyl-2',3'-anhydrothymidine with tetrazole or its 5-derivatives followed by debenzoylation. Structu...

Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine.

Nucleosides Nucleotides Nucleic Acids 27 , 1272-1281, (2008)

A general method is described for synthesizing 3',5'-dithio-2'-deoxypyrimidine nucleosides 6 and 13 from normal 2'-deoxynucleosides. 2,3'-Anhydronucleosides 2 and 9 are applied as intermediates in the...

2,3'-Anhydro-D-thymidine

Anhydrothymidine

2,3'-O-Cyclothymidine

5-methyl-2'-deoxy-2,3'-anhydrouridine

threo-2,3'-anhydro-thymidine

O2,3'-Cyclothymidine

2,3'-脱水胸苷

2,3'-脱水胸苷用途

2,3'-脱水胸苷名称

2,3'-脱水胸苷生物活性

2,3'-脱水胸苷物理化学性质

2,3'-脱水胸苷MSDS

2,3'-脱水胸苷安全信息

2,3'-脱水胸苷合成线路

2,3'-脱水胸苷文献2

2,3'-脱水胸苷英文别名

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