磷酸安他唑啉结构式
|
常用名 | 磷酸安他唑啉 | 英文名 | Antazoline |
|---|---|---|---|---|
| CAS号 | 154-68-7 | 分子量 | 363.348 | |
| 密度 | 0.975 g/mL at 25 °C(lit.) | 沸点 | 235-236 °C(lit.) | |
| 分子式 | C17H22N3O4P | 熔点 | 120-122ºC | |
| MSDS | 中文版 美版 | 闪点 | >230 °F | |
| 符号 |
GHS07 |
信号词 | Warning |
磷酸安他唑啉用途Antazoline phosphate is an antihistamine with anticholinergic properties used to relieve nasal congestion and the symptoms of allergic conjunctivitis. Antazoline is an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles. |
| 中文名 | N-苄基-4,5-二氢-N-苯基-1H-咪唑-2-甲胺磷酸盐 |
|---|---|
| 英文名 | N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,phosphoric acid |
| 中文别名 | 安它唑啉磷酸酯 | 磷酸安他唑啉 |
| 英文别名 | 更多 |
| 密度 | 0.975 g/mL at 25 °C(lit.) |
|---|---|
| 沸点 | 235-236 °C(lit.) |
| 熔点 | 120-122ºC |
| 分子式 | C17H22N3O4P |
| 分子量 | 363.348 |
| 闪点 | >230 °F |
| 精确质量 | 363.134796 |
| PSA | 115.20000 |
| LogP | 1.53070 |
| 蒸汽压 | 3.31E-09mmHg at 25°C |
| 折射率 | n20/D 1.517(lit.) |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:4 3.氢键受体数量:6 4.可旋转化学键数量:5 5.互变异构体数量:无 6.拓扑分子极性表面积105 7.重原子数量:25 8.表面电荷:0 9.复杂度:364 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302 + H312 + H332-H315-H319-H335 |
| 警示性声明 | P261-P280-P301 + P312 + P330-P305 + P351 + P338 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xn: Harmful; |
| 风险声明 (欧洲) | R20/21/22 |
| 安全声明 (欧洲) | S26-S36 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
|
Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.
Eur. J. Ophthalmol. 20(5) , 811-8, (2010) To compare the effects of topical antiallergic eyedrops in relieving the signs and symptoms of patients with allergic conjunctival pathology.In this multicenter, single-masked, randomized study, 240 p... |
|
|
Simultaneous determination of antazoline and naphazoline by the net analyte signal standard addition method and spectrophotometric technique.
J. AOAC Int. 93(6) , 1995-2001, (2010) A novel net analyte signal standard addition method (NASSAM) was used for simultaneous determination of the drugs anthazoline and naphazoline. The NASSAM can be applied for determination of analytes i... |
|
|
Determination of antihistamines based on the formation of mixed aggregates with surfactants.
Analyst 123(5) , 1079-84, (1998) The determination of antihistamines based on the measurement of the critical micelle concentration (c.m.c.) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassi... |
| 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-, phosphate (1:1) |
| Antazoline Phosphate |
| Antazoline phosphate (USP) |
| UNII-VPR5FPH326 |
| EINECS 205-831-4 |
| MFCD00054317 |
| Antazoline phosphate salt |
| 2-(N-Benzylanilinomethyl)-2-imidazoline |
| N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline phosphate (1:1) |
| 2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE |
