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Shear Stress-Enhanced Internalization of Cell Membrane Proteins Indicated by a Hairpin-Type DNA Probe
10.1021/acs.analchem.8b00755 2018-04-09 Shear stress is an important mechanical stimulus that plays a critical role in modulating cell functions. In this study, we investigated the regulating effects of shear stress on the internalization of cell membrane proteins in a microfluidic chip. A hairpin-... |
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Perceptual Image Quality Metrics Concept in Continuous Scanning 2D Laser Ablation-Inductively Coupled Plasma Mass Spectrometry Bioimaging
10.1021/acs.analchem.8b00751 2018-04-09 This work focuses on the structural similarity (SSIM) index as a tool for optimization of the perceived visual image quality obtainable by continuous scanning 2D LA-ICPMS bioimaging, but also other mass spec imaging techniques may benefit from this approach. ... |
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Live Cell Imaging in Microfluidic Device Proves Resistance to Oxygen/Glucose Deprivation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
10.1021/acs.analchem.7b05347 2018-04-09 Analyses of cellular responses to fast oxygen dynamics are challenging and require ad hoc technological solutions, especially when decoupling from liquid media composition is required. In this work, we present a microfluidic device specifically designed for c... |
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Azoreductase and Target Simultaneously Activated Fluorescent Monitoring for Cytochrome c Release under Hypoxia
10.1021/acs.analchem.8b00554 2018-04-09 Hypoxia-induced cell apoptosis is closely related to degenerative diseases, autoimmune disorders, and tumor disease. In the process of apoptosis, the release of cytochrome c (Cyt c) is deemed to be a critical factor of the intrinsic pathway. Strategies for tr... |
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Purification of Semiconducting Polymer Dots by Size Exclusion Chromatography Prior to Cytotoxicity Assay and Stem Cell Labeling
10.1021/acs.analchem.8b00095 2018-04-09 Semiconducting polymer dots (Pdots) as fluorescent probes have shown promising applications because of their excellent optical properties. However, apparent differences were observed in cytotoxicity assays, which might originate from impurities introduced in ... |
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Exploring Ion Suppression in Mass Spectrometry Imaging of a Heterogeneous Tissue
10.1021/acs.analchem.7b05005 2018-04-09 In this study we have explored several aspects of regional analyte suppression in mass spectrometry imaging (MSI) of a heterogeneous sample, transverse cryosections of mouse brain. Olanzapine was homogeneously coated across the section prior to desorption ele... |
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Hybrid Surface and Bulk Resonant Acoustics for Concurrent Actuation and Sensing on a Single Microfluidic Device
10.1021/acs.analchem.8b00466 2018-04-06 While many microfluidic devices have been developed for sensing and others for actuation, few devices can perform both tasks effectively and simultaneously on the same platform. In piezoelectric sensors and actuators, this is due to the opposing operating req... |
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Dichroic Mirror-Assisted Electrochemiluminescent Assay for Simultaneously Detecting Wild-type and Mutant p53 with Photomultiplier Tubes
10.1021/acs.analchem.8b00831 2018-04-06 The electrochemical-dependent and unstable intensity of electrochemiluminescence (ECL) makes it difficult to identify ECL in a waveband-resolved way on photomultiplier tube (PMT)-based traditional ECL analyzers. Herein, a dual-color ECL strategy is proposed b... |
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Molecular Machine Powered Surface Programmatic Chain Reaction for Highly Sensitive Electrochemical Detection of Protein
10.1021/acs.analchem.8b01217 2018-04-06 A bipedal molecular machine powered surface programmatic chain reaction was designed for electrochemical signal amplification and highly sensitive electrochemical detection of protein. The bipedal molecular machine was built through aptamer–target specific re... |
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Biomimetic Interfacial Electron-Induced Electrochemiluminesence
10.1021/acs.analchem.8b00165 2018-04-06 We provide here, for the first time, a new interfacial electron-induced electrochemiluminescence (IEIECL) system, realizing bionic construction of bioluminescence (BL) by exploiting electrochemiluminescence (ECL) and ITIES (the interface between two immiscibl... |