|
Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer
10.1016/j.nano.2017.12.011 2018-01-03 Nanoparticulate vaccines are promising tools to overcome cancer immune evasion. However, a deeper understanding on nanoparticle–immune cell interactions and treatments regime is required for optimal efficacy. We provide a comprehensive study of treatment sche... |
|
|
Extracellular vesicles or free circulating DNA: where to search for BRAF and cKIT mutations?
10.1016/j.nano.2017.12.009 2017-12-27 Clinical evidence in oncology argues for the advantages of performing molecular analysis of blood biomarkers to provide information about systemic changes and tumor heterogeneity. Whereas the diagnostic value of cell-free circulating DNA (fcDNA) has successfu... |
|
|
GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases
10.1016/j.nano.2017.12.007 2017-12-24 There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neur... |
|
|
Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles
10.1016/j.nano.2017.12.008 2017-12-24 Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the ... |
|
|
Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin
10.1016/j.nano.2017.12.002 2017-12-21 Virus-mimicking particles have made great contribution to the development of nanomedicine. Herein, several modularized peptides (lipophilic NS5A peptide, 6xHis tag, and tumor-targeting peptide RGD) were genetically inserted into the C-terminus and the major i... |
|
|
Delivery of microRNA-1 inhibitor by dendrimer-based nanovector: An early targeting therapy for myocardial infarction in mice
10.1016/j.nano.2017.12.004 2017-12-18 Myocardial infarction (MI), known to be rapidly progressed and fatal, necessitates a timely and effective intervention particularly within golden 24 h. The crux is to develop a therapeutic agent that can early target the infarct site with integrated therapeut... |
|
|
Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model
10.1016/j.nano.2017.12.006 2017-12-15 Alzheimer's disease (AD) is a neurodegenerative disorder related, in part, to the accumulation of amyloid-β peptide (Aβ) and especially the Aβ peptide 1-42 (Aβ1-42). The aim of this study was to design nanocarriers able to: (i) interact with the Aβ1-42 in the... |
|
|
Nanocellulose reinforced gellan-gum hydrogels as potential biological substitutes for annulus fibrosus tissue regeneration
10.1016/j.nano.2017.11.011 2017-11-21 Intervertebral disc (IVD) degeneration is related to both structural damage and aging. Annulus fibrosus (AF) defects such as annular tears, herniation and discectomy require novel strategies to functionally repair AF tissue. An ideal construct will repair the... |
|
|
Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts
10.1016/j.nano.2017.11.006 2017-11-16 Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are n... |
|
|
Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist
10.1016/j.nano.2017.10.015 2017-11-08 Rod-shaped virus-like nanoparticles (VLNP) made of papaya mosaic virus (PapMV) coat proteins (CP) self-assembled around a single stranded RNA (ssRNA) were showed to be a TLR7 agonist. Their utilization as an immune modulator in cancer immunotherapy was shown ... |