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Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates.
Bioconjug. Chem. 17(5) , 1360-3, (2006) 2006-01-01 An efficient method to synthesize hyaluronan oligosaccharide lipid conjugates is described. This strategy is based on the introduction of a double bond in the glucuronic acid of the hyaluronic acid (HA), by the biodegradation of HA with hyaluronate lyase, fol... |
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Epidermal growth factor-conjugated poly(ethylene glycol)-block- poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics.
Bioconjug. Chem. 17(2) , 399-409, (2006) 2006-01-01 Epidermal growth factor (EGF)-conjugated copolymer micelles were prepared from a mixture of diblock copolymers of methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) (MePEG-b-PVL) and EGF-PEG-b-PVL for targeted delivery to EGF receptor (EGFR)-overex... |
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Synthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell line.
Bioconjug. Chem. 17(3) , 689-99, (2006) 2006-01-01 Iberiotoxin (IbTx) is a scorpion venom peptide that inhibits BK Ca2+-activated K+ channels with high affinity and specificity. Automated solid-phase synthesis was used to prepare a biotin-labeled derivative (IbTx-LC-biotin) of IbTx by substitution of Asp19 of... |
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Design of phosphoramidite monomer for optimal incorporation of functional intercalator to main chain of oligonucleotide.
Bioconjug. Chem. 16(2) , 306-11, (2005) 2005-01-01 Chirally pure phosphoramidite monomers bearing 9-amino-6-chloro-2-methoxyacridine were synthesized from D- or L-threoninol and omega-aminocarboxylic acid, and incorporated into oligonucleotides. These acridine-DNA conjugates formed stable duplexes with comple... |
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Synthesis of new bivalent peptides for applications in the Affinity Enhancement System.
Bioconjug. Chem. 16(1) , 184-93, (2005) 2005-01-01 The feasibility of two-step radioimmunotherapy (RIT) of cancer by the Affinity Enhancement System (AES) has been demonstrated in experimental and clinical studies. This technique, associating a bispecific antibody and a bivalent peptide radiolabeled with iodi... |
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Multivalent carbocyanine molecular probes: synthesis and applications.
Bioconjug. Chem. 16(1) , 51-61, (2005) 2005-01-01 Synergistic multivalent interactions can amplify desired chemical or biological molecular recognitions. We report a new class of multicarboxylate-containing carbocyanine dye constructs for use as optical scaffolds that not only serve as fluorescent antennas b... |
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In vitro system to estimate renal brush border enzyme-mediated cleavage of Peptide linkages for designing radiolabeled antibody fragments of low renal radioactivity levels.
Bioconjug. Chem. 16(6) , 1610-6, (2005) 2005-01-01 Renal localization of radiolabeled antibody fragments presents a problem in targeted imaging and radiotherapy. We recently reported that Fab fragments labeled with 3'-[(131)I]iodohippuryl N(epsilon)-maleoyl-l-lysine (HML) demonstrated markedly low renal radio... |
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Example of fatty acid-loaded lipoplex in enhancing in vitro gene transfer efficacies of cationic amphiphile.
Bioconjug. Chem. 16(3) , 676-84, (2005) 2005-01-01 Herein, we report on the design and synthesis of a novel nontoxic cationic amphiphile N,N-di-n-tetradecyl-N-[2-[N',N'-bis(2-hydroxyethyl)amino]ethyl]-N-(2-hydroxyethyl)ammonium chloride (lipid 1) whose in vitro gene transfer efficacies in CHO, COS-1, MCF-7, a... |
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Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex.
Bioconjug. Chem. 16(5) , 1058-62, (2005) 2005-01-01 The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein-fullerene complex with a native protein has never been obs... |
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Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1.
Bioconjug. Chem. 16(2) , 377-82, (2005) 2005-01-01 Glucagon-like peptide-1-(7-36) (GLP-1) is a hormone derived from the proglucagon molecule, which is considered a highly desirable antidiabetic agent mainly due to its unique glucose-dependent stimulation of insulin secretion profiles. However, the development... |