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Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus
10.1016/j.bmcl.2018.03.080 2018-03-30 A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds w... |
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C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum
10.1016/j.bmcl.2018.03.078 2018-03-29 Eight new C21 steroidal glycosides, namely cynanotins A–H (1−8), together with fifteen known analogues, were isolated from the roots of Cynanchum otophyllum. Their structures were elucidated by spectroscopic analysis and chemical methods. In this study, all o... |
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Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET
10.1016/j.bmcl.2018.03.081 2018-03-29 By structure-activity relationship studies on the tilorone scaffold, the ‘one armed’ substituted dibenzothiophenes and the fluoren-9-ones were identified as the most potential α7 nAChR ligands. While the suitability of dibenzothiophene derivatives as PET trac... |
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Anticomplement compounds from Polygonum chinense
10.1016/j.bmcl.2018.03.079 2018-03-29 Five new compounds including two phenyldilactones (1, 2), two coumarins (3, 4) and a dimer of N-E-feruloyl tyramine (5) together with twenty-three known compounds (6-28) were isolated from a medicinal plant Polygonum chinense. The structures of the new compou... |
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Design, synthesis and biological evaluation of seco-A-pentacyclic triterpenoids-3, 4-lactone as potent non-nucleoside HBV inhibitors
10.1016/j.bmcl.2018.03.076 2018-03-29 A series of seco-A -pentacyclic triterpenoids-3, 4-lactone were synthesized and the anti-HBV activities were evaluated in vitro. Several compounds inhibited the secretion of HBV antigen and the replication of HBV DNA in micromolar level. Compounds D7 and D10,... |
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Catalytic Asymmetric Synthesis of α-Methyl-p-Boronophenylalanine
10.1016/j.bmcl.2018.03.075 2018-03-28 p-Boronophenylalanine (L-BPA) is applied in clinical settings as a boron carrier for boron neutron capture therapy (BNCT) to cure malignant melanomas. Structural modification or derivatization of L-BPA, however, to improve its uptake efficiency into tumor cel... |
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Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents
10.1016/j.bmcl.2018.03.074 2018-03-28 A new series of 1,2,4-triazole-linked urea and thiourea conjugates have been synthesized and evaluated for their in vitro cytotoxicity against selected human cancer cell lines namely, breast (MCF-7, MDA-MB-231), lung (A549) prostate (DU145) and one mouse mela... |
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Beta-Sitosterol and Its Derivatives Repress Lipopolysaccharide / D-galactosamine-induced Acute Hepatic Injury by Inhibiting the Oxidation and Inflammation in Mice
10.1016/j.bmcl.2018.03.073 2018-03-28 Beta-sitosterol (Sit) widely exists in natural plants, is classed as phytosterol and known as the “key of life”. Most pharmacological studies and clinical applications are limited because of the fact that Sit is difficult to be solved. Therefore, it is viable... |
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Erratum to “Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes” Bioorg. Med. Chem. Lett. 28 (2018) [841–846]
10.1016/j.bmcl.2018.03.053 2018-03-28
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Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity
10.1016/j.bmcl.2018.03.068 2018-03-27 New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position ... |