考布他丁 A-4 磷酸二钠盐
更新时间：2024-09-16 16:05:43
| 常用名 | 康普瑞汀磷酸二钠 | CAS号 | 168555-66-6 |
|---|---|---|---|
| 价格 | ￥需询单/20mg | 纯度 | 98.0% |
| 备货期 | 1天 | 库存 | 900 mg |
| 产品详情（用途，包装等）
用途： Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.IC50 Value: 4 nM [1]Target: microtubulein vitro: Cytotoxic IC(50) values of CA-4 in human bladder cancer cells were below 4 nM. Analyses of cell-cycle distribution showed CA-4 obviously induced G(2)-M phase arrest with sub-G(1) formation. The analyses of apoptosis showed that CA-4 induced caspase-3 activation and decreased BubR1 and Bub3 in cancer cells [1]. The enhanced apoptosis induced by dasatinib plus CA-4 was accompanied by a greater extent of mitochondrial depolarization, caspase-3 activation and PARP cleavage in HO-8910 cells. Furthermore, elevated expression of Mcl-1 led to a reduced apoptosis induced by dasatinib plus CA-4, highlighting that downregulated Mcl-1 was necessary for the potentiating effect of dasatinib to CA-4-triggered apoptosis [2].in vivo: The increased anticancer efficacy of dasatinib combined with CA-4 was further validated in a human HO-8910 ovarian cancer xenograft model in nude mice [2]. There was a significant, concentration dependent increase in mean arterial blood pressure with a maximum increase of about 60% of the baseline MAP at 30 mg/kg of CA4P compared to the saline control. However, there was no significant increase in the cardiac troponin I level after CA4P injection [3].Clinical trial: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome [4]. 物理化学性质： CAS号：168555-66-6 常用中文名：康普瑞汀磷酸二钠 常用英文名：Combretastatin A4 disodium phosphate 分子式：C18H19Na2O8P 分子量：440.292 密度：N/A 沸点：611.8ºC at 760 mmHg 熔点：238-242ºC 闪点：N/A 储存条件：Refrigerator |
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Fosbretabulin disodium
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：康普瑞汀A4磷酸二钠
- 价格： ￥586.9/10mg ￥1410.9/50mg ￥需询单/1g ￥需询单/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
查看所有供应商和价格请点击：
参考价格：$127/10mM*1mLinWater