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常用名 | 利拉鲁肽 | CAS号 | 204656-20-2 |
|---|---|---|---|---|
| 价格 | $233.5/10mg $3886.86/1g | 纯度 | 99.46% | |
| 备货期 | 3天 | 库存 | 现货 | |
| 产品网页 | http://www.zhaokebio.com | |||
| 产品详情(用途,包装等)
Liraglutide is a 31-amino acid synthetic peptide analog of human glucagon-like peptide-1 (GLP-1) with 97% amino acid sequence homology to endogenous human GLP-1(7-37). It is a long-acting GLP-1 receptor agonist featuring a unique C16 fatty acid (palmitic acid) side chain conjugated to Lys26 via a glutamic acid spacer, enabling prolonged half-life through albumin binding. Liraglutide is the first acylated GLP-1 analog to achieve once-daily dosing, establishing the foundational design principle for modern GLP-1 therapeutics. Liraglutide binds to and activates the GLP-1 receptor, a G-protein coupled receptor expressed in pancreatic islet beta-cells, hypothalamus, and other tissues. Receptor activation increases intracellular cyclic AMP (cAMP), triggering glucose-dependent insulin secretion from beta-cells while suppressing glucagon secretion from alpha-cells at elevated glucose concentrations. Additionally, liraglutide exerts anorexigenic effects by stimulating POMC/CART neurons and inhibiting NPY/AgRP neurons in the arcuate nucleus of the hypothalamus, leading to reduced appetite and caloric intake. It also delays gastric emptying, contributing to improved postprandial glycemic control. |
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