| 常用名 | 盐酸阿那格雷 | CAS号 | 58579-51-4 |
|---|---|---|---|
| 价格 | ¥需询单/100g ¥需询单/500g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 33 |
| 产品详情(用途,包装等)
用途: Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.Target: PDEAnagrelide hydrochloride is an oral imidazoquinazoline agent that has been shown to reduce elevated platelet counts and the risk of thrombosis in patients with thrombocythaemia in various myeloproliferative disorders (MPD). It is currently approved by the FDA as oral treatment for essential thrombocythaemia (ET) and thrombocythaemia associated with polycythaemia vera (PV). Anagrelide is known to inhibit platelet cyclic adenosine monophosphate (cAMP) phosphodiesterase at concentrations that exceed those achieved at doses used to treat ET. Anagrelide is extensively metabolised in the liver and its metabolites are primarily excreted in the urine [1]. Anagrelide is an established platelet-reducing drug. Studies have also investigated the effects of anagrelide on platelets, indicating that platelet function is as important as platelet counts in ET [2]. 物理化学性质: CAS号:58579-51-4 常用中文名:盐酸阿那格雷 常用英文名:Anagrelide HCl 分子式:C10H8Cl3N3O 分子量:292.549 密度:1.77g/cm3 沸点:376.5ºC at 760 mmHg 熔点:>280ºC 闪点:181.5ºC 储存条件:Desiccate at +4°C |