常用名 | 高牛磺酸 | CAS号 | 3687-18-1 |
---|---|---|---|
价格 | ¥需询单/25kg | 纯度 | 98.0% |
备货期 | 需询单 | 库存 | 3 |
产品详情(用途,包装等)
用途: Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg. 物理化学性质: CAS号:3687-18-1 常用中文名:高牛磺酸 常用英文名:Tramiprosate 分子式:C3H9NO3S 分子量:139.173 密度:1.4±0.1 g/cm3 沸点:N/A 熔点:293 °C (dec.)(lit.) 闪点:N/A 储存条件:Store at 0-5°C |