| 常用名 | 达卡巴嗪 | CAS号 | 4342-03-4 |
|---|---|---|---|
| 价格 | ¥需询单/500g ¥需询单/1kg ¥需询单/25kg ¥需询单/200kg | 纯度 | 0.0% |
| 备货期 | 需询单 | 库存 | 有现货 |
| 产品详情(用途,包装等)
用途: Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.Target: Nucleoside antimetabolite/analogApproved: May 1975Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3]. 物理化学性质: CAS号:4342-03-4 常用中文名:达卡巴嗪 常用英文名:Dacarbazine 分子式:C6H10N6O 分子量:182.183 密度:1.5±0.1 g/cm3 沸点:456.3±55.0 °C at 760 mmHg 熔点:199-205°C 闪点:229.7±31.5 °C 储存条件:2-8°C |