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常用名 甘罗溴铵 CAS号 596-51-0
价格 ¥需询单/500g ¥需询单/1kg ¥需询单/25kg ¥需询单/200kg 纯度 0.0%
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 产品详情(用途,包装等)
用途:
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.IC50 Value:Target: mAChR (Muscarinic acetylcholine receptor M1)in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Kinetics studies, however, showed that glycopyrrolate dissociates slowly from HASM muscarinic receptors (60% protection against [3H]-NMS binding at 30 nM) compared to ipratropium bromide [1].in vivo: Glycopyrrolate (1 mg) tablets were then administered, starting with one tablet daily the third week and increasing the daily dose by one tablet per week until a maximum of four tablets during week six and 4 days of week seven when the daily dose was reduced to two tablets for 3 days. glycopyrrolate can be given in controlled doses provided that an adequate medical assessment has been undertaken [2]. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect [3]. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children [4]. phase III study, 52.3% of glycopyrrolate oral solution recipients (aged 3-18 years; n = 137) had an mTDS response (primary endpoint); the response rate was consistently above 50% at all 4-weekly timepoints, aside from the first assessment at week 4 (40.3%). In general, glycopyrrolate oral solution was well tolerated in clinical trials. The majority of adverse events were within expectations as characteristic anticholinergic outcomes [5].Toxicity: Side effects include dry mouth, difficult urinating, heachaches, diarrhea and constipation. The medication also induces drowsiness or blurred vision. LD50=709 mg/kg (rat, oral).
物理化学性质:
CAS号:596-51-0
常用中文名:甘罗溴铵
常用英文名:Glycopyrrolate
分子式:C19H28BrNO3
分子量:398.335
密度:N/A
沸点:N/A
熔点:193 - 194.5ºC
闪点:N/A
储存条件:Hygroscopic, -20°C Freezer, Under Inert Atmosphere

供应商信息

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参考价格:$66/10mM*1mLinWater
其他供应商价格:
2022-02-19 甘罗溴铵
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2019-03-05 甘罗溴铵
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2026-03-10 甘罗溴铵
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2023-11-18 Glycopyrrolate
价格:¥需询单
2024-07-15 格隆溴铵
价格:需询单
2024-04-24 格隆溴铵,甘罗溴铵
价格:¥需询单
2021-02-06 Glycopyrrolate
价格:¥489.0
2017-08-07 甘洛溴铵
价格:¥需询单

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