常用名 | 14-3-3 inhibitor BV2 | CAS号 | 302602-92-2 |
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价格 | ¥需询单/100mg ¥需询单/250mg ¥需询单/1g | 纯度 | 98.0% |
备货期 | 10天 | 库存 | 现货 |
产品详情(用途,包装等)
用途: A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation; induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively; promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels, induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. 物理化学性质: CAS号:302602-92-2 常用中文名:14-3-3 inhibitor BV2 常用英文名:14-3-3 inhibitor BV2 分子式:C20H17N3O6 分子量:395.366 密度:1.5±0.1 g/cm3 沸点:N/A 熔点:N/A 闪点:N/A |