ND2158
更新时间：2024-07-17 16:20:38
采购访问：47次
| 常用名 | ND2158 | CAS号 | 1388896-07-8 |
|---|---|---|---|
| 价格 | ￥需询单/100mg ￥需询单/250mg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： ND2158 (ND-2158) is a highly potent and selective IRAK4 inhibitor with IC50 of 1.3 nM;ND2158 demonstrates high selectivity against 334 kinases, and >1000-fold over IRAK1.ND2158 blocked TNF production, collagen-induced arthritis, and gout formation in mice, suppressed LPS-induced TNF production, alleviated collagen-induced arthritis, and blocked gout formation in mouse models.IRAK4 inhibition promoted killing of ABC DLBCL lines harboring MYD88 L265P, by down-modulating survival signals, including NF-κB and autocrine IL-6/IL-10 engagement of the JAK-STAT3 pathway.In ABC DLBCL xenograft models, IRAK4 inhibition suppressed tumor growth as a single agent, and in combination with the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib or the Bcl-2 inhibitor ABT-199. 物理化学性质： CAS号：1388896-07-8 常用中文名：ND2158 常用英文名：ND2158 分子式：C22H30N4O4S 分子量：446.566 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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