A-836339
更新时间：2024-07-15 12:38:00
采购访问：16次
| 常用名 | A-836339 | CAS号 | 959746-77-1 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： A-836339 is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors.IC50 value: 1.6 nM(EC50) [1]Target: CB2 agonistin vitro: In radioligand binding assays, A-836339 displays high affinities at CB(2) receptors and selectivity over CB(1) receptors in both human and rat.In addition A-836339 exhibits a profile devoid of significant affinity at other G-protein-coupled receptors and ion channels [1].in vivo: In the complete Freund's adjuvant model of inflammatory pain, A-836339 exhibits a potent CB(2) receptor-mediated antihyperalgesic effect that is independent of CB(1) or mu-opioid receptors. A-836339 has also demonstrated efficacies in the chronic constrain injury (CCI) model of neuropathic pain, skin incision, and capsaicin-induced secondary mechanical hyperalgesia models [1]. Similar to systemic delivery, intra-spinal injection of A-836339 (0.3 and 1 nmol) also attenuated both von Frey-evoked and spontaneous firing of WDR neurons in neuropathic rats. Intra-spinal injections of A-836339 were ineffective in sham rats [2]. Systemic A-836339 and AM1241 produced dose-dependent efficacy in both inflammatory and neuropathic pain models. Local administration of CB? agonists also produced significant analgesic effects in SNL (intra-DRG and i.t.) and CFA (intra-DRG) pain models [3]. 物理化学性质： CAS号：959746-77-1 常用中文名：A-836339 常用英文名：A-836339 分子式：C16H26N2O2S 分子量：310.455 密度：1.1±0.1 g/cm3 沸点：388.4±44.0 °C at 760 mmHg 熔点：N/A 闪点：188.7±28.4 °C 储存条件：2-8℃ |
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- 产品名：A-836339
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$164/10mM*1mLinDMSO