| 常用名 | 2',3'-二脱氧-3'-氟鸟苷 | CAS号 | 92562-88-4 |
|---|---|---|---|
| 价格 | 纯度 | 99.84% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value:Target: Anti-HBV compoundOral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. 物理化学性质: CAS号:92562-88-4 常用中文名:2',3'-二脱氧-3'-氟鸟苷 常用英文名:Lagociclovir 分子式:C10H12FN5O3 分子量:269.232 密度:2.0±0.1 g/cm3 沸点:633.5±65.0 °C at 760 mmHg 熔点:N/A 闪点:336.9±34.3 °C |