STINGagonist-1
更新时间：2025-09-09 13:58:40
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| 常用名 | STING激动剂-1 | CAS号 | 702662-50-8 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) (IC90 = 24.57 μM). IC50 value: 24.57 μM (IC90)Target: VEEV, STINGin vitro: G10 does not bind to STING directly, however, G10 represents the first synthetic small molecule characterized as an indirect activator of human STING-dependent phenotypes.100 μM G10 (a concentration over twelve times the IC90 for CHIKV and over four times the IC90 for VEEV). G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 Induces IFN/IRF3- but not NF-κB-Dependent Transcription in Human Fibroblasts. G10 activates IRF3, but not canonical NF-κB pathways in human fibroblasts. G10 elicits antiviral activity against New and Old World Alphaviruses. G10 stimulates phosphorylation of IFN regulatory factor 3 (IRF3) in a manner similar to that triggered by UV-inactivated cytomegalovirus (UV-CMV) and Sendai virus (SeV). G10 induces synthesis and secretion of bioactive type I and III IFNs and generates an antiviral state in fibroblast cells positive for STING, IRF3, and STAT1 proteins. G10 triggers innate immune responses that involve expression of IRF3-dependent genes including type I and III interferons. 物理化学性质： CAS号：702662-50-8 常用中文名：STING激动剂-1 常用英文名：G10, STING signaling activator 分子式：C21H16ClFN2O3S 分子量：430.880 密度：1.4±0.1 g/cm3 沸点：668.3±55.0 °C at 760 mmHg 熔点：N/A 闪点：358.0±31.5 °C 储存条件：2-8℃ |
上海化源世纪贸易有限公司
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：G10, STING signaling activator
- 价格： ￥308.9/1mg ￥8136.9/100mg ￥1586.9/10mg ￥2523.9/25mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：STINGagonist-1
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$462/10mM*1mLinDMSO