4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮
更新时间：2025-09-14 18:44:44
采购访问：16次
| 常用名 | 吡噻硫酮 | CAS号 | 64224-21-1 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Oltipraz has an inhibitory effect on HIF-1α activation by insulin in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.IC50 value: 10 μMTarget: HIF-1αin vitro: Oltipraz inhibits HIF-1α activity and HIF-1α-dependent tumor growth, which may result from a decrease in HIF-1α stability through S6K1 inhibition in combination with an H2O2-scavenging effect. Oltipraz treatment also inhibits HIF-1α activation stimulated by either hypoxia or CoCl2. Oltipraz is a cancer chemopreventive agent and has an inhibitory effect on angiogenesis and tumor growth. [1] Oltipraz is also a competitive inhibitor of this cytochrome P450, with an apparent Ki of 10 μM. [2]in vivo: In wild-type mice, hepatic levels of mRNA for all of the genes analyzed were significantly increased after Oltipraz treatment, with the highest increase (treated/control) for NQO1 mRNA levels (7.6-fold). The Northern blot analyses demonstrated that the observed increases in GST and NQO1 activities by Oltipraz in wild-type mice were preceded by significant elevations in RNA expression. Interestingly, mRNA levels of Nrf2 itself were increased more than 3-fold by Oltipraz treatment. [2] 物理化学性质： CAS号：64224-21-1 常用中文名：吡噻硫酮 常用英文名：Oltipraz 分子式：C8H6N2S3 分子量：226.342 密度：1.5±0.1 g/cm3 沸点：408.1±55.0 °C at 760 mmHg 熔点：165-166ºC 闪点：200.6±31.5 °C 储存条件：2-8°C |
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- 产品名：4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/250mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
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参考价格：￥390/50mg