酸藤子酚
更新时间：2025-08-27 08:45:08
采购访问：58次
| 常用名 | 恩贝灵； 恩贝酸 | CAS号 | 550-24-3 |
|---|---|---|---|
| 价格 | 纯度 | 97.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide).IC50 value: 4.1 uM [1]Target: XIAPin vitro: Embelin induced activation of caspase-9 and embelin-induced apoptosis was prevented by caspase inhibitors [2]. Treatment with subtoxic doses of Embelin broadly sensitized malignant glioma cells to TRAIL-mediated apoptosis. Notably, human astrocytes were not significantly affected by the combined treatment consisting of Embelin and TRAIL. Combined treatment with Embelin and TRAIL augmented the activation of initiator caspases-8/-9 and effector caspases-3/-7, respectively [3]. in vivo: Embelin inhibited topical edema in the mouse ear, leading to substantial reductions in skin thickness and tissue weight, inflammatory cytokine production, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. Furthermore, embelin was effective at reducing inflammatory damage induced by chronic TPA exposure [4]. Embelin (10, 30 or 50mg/kg body weight) was administrated daily per oral route for 7days. Embelin significantly attenuated DSS-induced DAI scores and tissue MPO accumulation, which implied that it suppressed weight loss, diarrhea, gross bleeding, and the infiltrations of immune cells. Embelin administration also effectively and dose-dependently prevented shortening of colon length and enlargement of spleen size [5]. 物理化学性质： CAS号：550-24-3 常用中文名：恩贝灵； 恩贝酸 常用英文名：Embelin 分子式：C17H26O4 分子量：294.386 密度：1.131 沸点：431.9±45.0 °C at 760 mmHg 熔点：145-146 ºC 闪点：229.1±25.2 °C 储存条件：Store at +4°C |
上海化源世纪贸易有限公司
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地址：上海市普陀区金沙江路1759号圣诺亚大厦B座
地区： 上海市 上海市 普陀区
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主要合作伙伴：
- 云南西力生物技术股份有限公司
- 云南省 昆明市 盘龙区
- 产品名：恩贝酸
- 价格： ￥需询单/5mg
- 纯度：98.0%
- 备货期：10天
- 联系人：郑雪平
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：恩贝酸
- 价格： ￥1366.9/100mg ￥2344.9/250mg ￥514.9/25mg ￥144.9/5mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：酸藤子酚
- 价格：
- 纯度：97.0%
- 备货期：10天
- 联系人：徐经理
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：酸藤子酚
- 价格： ￥688.0/20mg
- 纯度：98.0%
- 备货期：1天
- 联系人：刘佳
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参考价格：￥1092/50mg