硫酸阿扎那韦
更新时间：2025-09-15 12:25:42
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| 常用名 | 阿扎那韦硫酸盐 | CAS号 | 229975-97-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.Target: HIV-1 protease inhibitorAtazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. It has a pharmacokinetic profile that supports once-daily dosing and has demonstrated a unique resistance profile and superior virologic potency compared with other antiretrovirals in vitro. In subjects with HIV, atazanavir (400 mg once daily) produced rapid and sustained improvements in viral load and CD4 counts in both antiretroviral-naive as well as previously treated patients when used in combination with dual nucleoside reverse transcriptase inhibitor (NRTI) treatment [1].After intravenous (iv), oral (po) and intraportal (ip) administration of ATV at a dosage of 7 mg/kg, AUCs in HL rats were 12.41, 5.24 and 8.89 microg/mLh, respectively, and were significantly higher than those in control rats (4.09, 1.70 and 3.38 microg/mLh). Despite the decrease of distribution volume (Vd(ss)), the terminal half-life (t(1/2)) in HL tended to be shorter than in control, and hepatic distribution of ATV in HL rats was 4.8-fold increases. These results suggested that the uptake of ATV into liver might counteract the decrease of Vd(ss). On the other hand, there was no significant difference in bioavailability, and the lymphatic transport to AUC showed no statistical change. In conclusion, although the protein binding rate and AUC were significantly increased, the pharmacokinetics of ATV might be tolerated in HL [2].Clinical indications: HIV-1 infection Toxicity: torsades de pointes 物理化学性质： CAS号：229975-97-7 常用中文名：阿扎那韦硫酸盐 常用英文名：Atazanavir sulfate 分子式：C38H54N6O11S 分子量：802.934 密度：1.164g/cm3 沸点：995.5ºC at 760 mmHg 熔点：195.0°, or acetone; mp 198-199° (dec) 闪点：555.8ºC 储存条件：<0°C;存放于惰性气体之中;避免空气,加热 |
上海化源世纪贸易有限公司
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- 产品名：硫酸阿扎那韦
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Atazanavir Sulfate
- 价格： ￥72.9/50mg ￥41.9/5mg ￥51.9/10mg ￥144.9/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：￥452.4/10mg