EBE-A22
更新时间：2025-09-08 23:54:27
采购访问：25次
| 常用名 | EBE-A22 | CAS号 | 229476-53-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.IC50 value: Target: The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designated EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. The present study was performed to explore the possibility that PD153035 and its N-methyl analogue might interact with double-stranded DNA, which is a primary target for many conventional antitumor agents. We studied the strength and mode of binding to DNA of PD153035 and EBE-A22 by means of absorption, fluorescence, and circular and linear dichroism as well as by a relaxation assay using human DNA topoisomerases. The results of various optical and gel electrophoresis techniques converge to show that both drugs bind to DNA and behave as typical intercalating agents. In particular, EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. Extensive DNase I footprinting experiments performed with a large range of DNA substrates show that EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control. 物理化学性质： CAS号：229476-53-3 常用中文名：EBE-A22 常用英文名：EBE-A22 分子式：C17H16BrN3O2 分子量：374.23200 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃ |
上海化源生化科技有限公司
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：EBE-A22
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：化源
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：EBE-A22
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：N-(3-溴苯基)-6,7-二甲氧基-N-甲基-4-喹唑啉胺
- 价格： ￥12472.9/100mg ￥2680.9/10mg ￥5360.9/25mg ￥8017.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：EBE-A22
- 价格： ￥需询单/1g ￥需询单/5g
- 纯度：98.0%
- 备货期：需询单
- 联系人：周经理
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参考价格：$227/10mM*1mLinDMSO