1-(叔丁基)-3-(萘-1-基)-1H-吡唑[3,4-d]嘧啶-4-胺
更新时间：2025-09-15 17:46:08
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| 常用名 | 4-氨基-1-叔丁基-3-(1’-萘)吡唑并[3,4-d]嘧啶 | CAS号 | 221243-82-9 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： 1-Naphthyl PP1(1-NA-PP 1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).IC50 Value:1.0 uM (v-Src); 0.6 uM (c-Fyn); 18 uM (c-Abl) [1]Target: Src Family kinase1-NA-PP1 was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. 1-NA-PP1 was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest. Overexpression of PKD1 or PKD3 almost completely reversed the growth arrest and the inhibition of tumor cell invasion caused by 1-NA-PP1, indicating that its anti-proliferative and anti-invasive activities were mediated through the inhibition of PKD. Interestingly, a 12-fold increase in sensitivity to 1-NA-PP1 could be achieved by engineering a gatekeeper mutation in the active site of PKD1, suggesting that 1-NA-PP1 could be paired with the analog-sensitive PKD1(M659G) for dissecting PKD-specific functions and signaling pathways in various biological systems [2]. 物理化学性质： CAS号：221243-82-9 常用中文名：4-氨基-1-叔丁基-3-(1’-萘)吡唑并[3,4-d]嘧啶 常用英文名：1-Naphthyl PP1 分子式：C19H19N5 分子量：317.388 密度：1.3±0.1 g/cm3 沸点：527.8±45.0 °C at 760 mmHg 熔点：219-222ºC 闪点：273.0±28.7 °C 储存条件：2-8℃ |
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- 产品名：1-(叔丁基)-3-(萘-1-基)-1H-吡唑[3,4-d]嘧啶-4-胺
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：￥578/5mg