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1-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-3,3-二甲基吲哚啉-2-酮盐酸盐

更新时间：2025-09-03 22:23:10 采购访问：30次

	常用名	1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐	CAS号	192927-92-7
	价格		纯度	98.0%
	备货期	10天	库存	现货

产品详情（用途，包装等）用途： LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.IC50 value: 249 nM (Ki) [1]Target: 5-HT1D in vitro: LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40% [1]. LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan [2]. in vivo: Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312±43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases basal levels of 5-HT above vehicle controls, reaching a maximum of 258% compared to the pre-injection control [1]. 物理化学性质： CAS号：192927-92-7 常用中文名：1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐常用英文名：LY310762 分子式：C24H28ClFN2O2 分子量：430.94300 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：Desiccate at RT

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