3-(环丙基甲氧基)-5,5-二甲基-4-[4-(甲基磺酰基)苯基]-2(5H)-呋喃酮
更新时间：2025-08-20 13:33:06
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| 常用名 | 非罗考昔 | CAS号 | 189954-96-9 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Firocoxib(ML 1785713) is a potent and selective cyclooxygenase (COX)-2 inhibitor with IC50 of 0.13 uM, 58 fold sensitivity for COX2 VSCOX1.IC50 value: 0.13 uM [1]Target: COX2 inhibitorin vitro: Blood concentrations resulting in 50% inhibition of COX-1 and COX-2 activity in vitro were 75 +/- 2 microM and 0.13 +/- 0.03 microM, respectively, and selectivity for inhibiting COX-2 relative to COX-1 was 58. Firocoxib had moderate to high oral bioavailability (54% to 70%), low plasma clearance (4.7 to 5.8 mL/min/kg), and an elimination half-life of 8.7 to 12.2 hours [1]. in vivo: Administration of firocoxib did not cause any adverse effects on GI, or hematological or serum biochemical variables and appears to have been well tolerated by dogs [2]. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14-day washout period, animals received firocoxib orally prior to cautery dehorning. Firocoxib concentrations were determined by liquid chromatography-tandem mass spectrometry [3]. Firocoxib 5 mg/kg was given orally once daily for 180 days to five dogs with clinical signs and histopathological lesions consistent with solar dermatitis/actinic keratosis. On days 0, 50 and 180, the severity of erythema, skin shine, induration and the number of comedones were evaluated by a clinical scoring system [4]. 物理化学性质： CAS号：189954-96-9 常用中文名：非罗考昔 常用英文名：Firocoxib 分子式：C17H20O5S 分子量：336.403 密度：1.3±0.1 g/cm3 沸点：563.9±50.0 °C at 760 mmHg 熔点：78-80°C 闪点：294.8±30.1 °C 储存条件：-20?C Freezer |
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：3-(环丙基甲氧基)-5,5-二甲基-4-[4-(甲基磺酰基)苯基]-2(5H)-呋喃酮
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：Firocoxib
- 价格： ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：周经理
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参考价格：$158/10mM*1mLinDMSO