5,6-二氢-2,3-二甲氧基-6,6-二甲基苯并[7,8]吲哚嗪并[2,3-B]喹喔啉
更新时间：2025-09-12 13:34:55
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| 常用名 | YM-90709 | CAS号 | 163769-88-8 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： YM-90709 is a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.Target: IL-5in vitro: YM-90709 potently inhibits the binding of 100 pM [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0±0.40 and 0.57±0.21 μM, respectively. YM-90709 inhibits the 4 pM IL-5-induced effect in a concentration-dependent manner with an IC50 value of 0.45±0.024 μM. YM-90709 also inhibits the higher concentrations (12 and 40 pM) of IL-5-induced effects with IC50 values of 0.89±029 and 1.0±0.22 μM, respectively. [1] YM-90709 is a novel interleukin-5 receptor antagonist, YM-90709 inhibits antigen-induced eosinophil recruitment into the airway, the same as anti-IL-5 mAb does. YM-90709 inhibits the binding of IL-5 to IL-5R on human eosinophils, but did not inhibit the binding of GM-CSF to GM-CSFR. In addition, YM-90709 inhibits IL-5-induced, but not GM-CSF-induced, eosinophil survival as well as the tyrosine phosphorylation of Janus kinase 2. [2]in vivo: YM-90709 suppresses antigen-induced airway inflammation in Brown Norway rats . YM-90709 is a novel IL-5R antagonist with those of anit-IL-5 mAb on the antigen-induced infiltration of eosinophils into the airways of BDF1 mice, a strain that is commonly used in the antibody estimation. [2] This is the first report on the examination of the effects of YM-90709 in vivo, as a novel IL-5R antagonist on the antigen-induced infiltration of eosinophils and other leukocytes into the BALF of Brown-Norway (BN) rats. [3] 物理化学性质： CAS号：163769-88-8 常用中文名：YM-90709 常用英文名：YM-90709 分子式：C22H21N3O2 分子量：359.421 密度：1.3±0.1 g/cm3 沸点：579.6±50.0 °C at 760 mmHg 熔点：N/A 闪点：304.3±30.1 °C 储存条件：-20℃ |
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- 产品名：YM 90709
- 价格： ￥834.9/10mg ￥246.9/2mg ￥5561.9/250mg ￥2471.9/50mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：5,6-二氢-2,3-二甲氧基-6,6-二甲基苯并[7,8]吲哚嗪并[2,3-B]喹喔啉
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
351666998
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133 1186 9306
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参考价格：$132/10mM*1mLinDMSO