| 常用名 | 脂肪抑素A. | CAS号 | 125256-00-0 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Fatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cellstarget: SREBPIC50: 2.5 ~10 μMIn vitro: Fatostatin A suppress cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. [1] Fatostatin potently inhibited cell growth.[2]In vivo: Fatostatin A cause G2/M cell cycle arrest and induce apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. [1] μCT analyses show that fatostatin A treatment preserve bone mass and structure in the proximal tibial trabecular bone in the mouse RANKL-induced bone loss model.[3] 物理化学性质: CAS号:125256-00-0 常用中文名:脂肪抑素A. 常用英文名:Fatostatin A 分子式:C18H18N2S 分子量:294.41400 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A 储存条件:2-8℃ |