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利塞膦酸

更新时间:2025-08-21 16:49:18 采购访问:32次

常用名 利塞膦酸 CAS号 105462-24-6
价格 纯度 99.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
Risedronic acid (Risedronate ) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.Target: OthersRisedronate, which was promoted in Croatia a few months ago, is the latest (III) generation of bisphosphonates, the most efficient anti-resorption drugs that inhibit osteoclast-mediated bone resorption and change the bone metabolism. Risedronate is hence the first line of bisphosphonates for the reduction of vertebral and non-vertebral fracture risks in postmenopausal women with osteoporosis or those with a high risk of osteoporosis. It also efficiently prevents bone loss or improves bone density in men and women on a long-term corticosteroid therapy .The administration of 20 and 25 mg/kg risedronate for 4 days led to decreases of parasitemia of 68.9% and 83.6%, respectively. On the seventh day of treatment the inhibitions were 63% and 88.9% with 20 and 25 mg/kg, respectively. After recovering the parasitemia, a dose-response curve was obtained for estimating the ID50 (dose causing 50% inhibition), equivalent to 17 ± 1.8 mg/kg after 7 days of treatment. Four days after the interruption of treatment (11 days postinfection), the parasitemias of the groups treated with 10, 15, 20, and 25 mg/kg/day were 15.3%, 15.9%, 15.2%, and 5.7%, respectively. Conversely, the group that received PBS presented parasitemia of 25.6%. Among the groups treated with risedronate, only the animals that received 25 mg/kg had a significant inhibition of 77.8% (see Table S1 in the supplemental material), demonstrating that even after treatment discontinuation, the parasitemia of the animals remained low in relation to that of the controls .
物理化学性质:
CAS号:105462-24-6
常用中文名:利塞膦酸
常用英文名:Risedronic acid
分子式:C7H11NO7P2
分子量:283.112
密度:1.9±0.1 g/cm3
沸点:692.3±65.0 °C at 760 mmHg
熔点:N/A
闪点:372.5±34.3 °C
储存条件:2~8°C

供应商信息

上海化源世纪贸易有限公司 认证供应商

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参考价格:$86/100mg
其他供应商价格:
2024-09-13 利塞膦酸
价格:¥需询单
2017-07-11 利塞膦酸
价格:¥需询单
2021-02-06 Risedronate
价格:¥789.0
2024-01-09 TIANFUCHEM--105462-24-6--High purity Risedronic acid factory price
价格:$需询单

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