托吡酯
更新时间：2024-07-15 12:38:02
采购访问：17次
| 常用名 | 托吡酯 | CAS号 | 97240-79-4 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.Target: GluR5 receptor; GABA receptorTopiramate (Topamax) is a structurally novel broad-spectrum antiepileptic drug (AED) with established efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatric patients with generalised tonic-clonic seizures, partial seizures with or without generalised seizures, and seizures associated with Lennox-Gastaut syndrome [1]. topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (gamma-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors [2].Topiramate (median average dosage 5.1 mg/kg/day) was also found to be useful as adjunctive therapy in the management of Lennox-Gastaut syndrome and significantly reduced the mean frequency of drop attacks by 14.8% compared with an increase of 5.1% with placebo. Further gains in seizure control were made in a nonblind extension of this trial where the mean topiramate dosage was 10 mg/kg/day. Nine of 11 patients in 1 pilot trial of children with otherwise intractable West syndrome, and 5 of 10 in another, achieved a > or =50% reduction in seizure rate with topiramate (target dosage up to 24 mg/kg/day) [3].Clinical indications: Epilepsy; Lennox Gastaut syndrome; Migraine; Seizure disorder Toxicity:abdominal pain; agitation; blurred vision; convulsions; depression; dizziness; double vision; drowsiness; impaired coordination; impaired mental activity; low blood pressure; reduced consciousness; severe diarrhea; sluggishness and speech problems. 物理化学性质： CAS号：97240-79-4 常用中文名：托吡酯 常用英文名：Topiramate 分子式：C12H21NO8S 分子量：339.362 密度：1.3±0.1 g/cm3 沸点：438.7±55.0 °C at 760 mmHg 熔点：125ºC 闪点：219.1±31.5 °C 储存条件：0-10°C;避免加热 |
上海念兴实业有限公司
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商品数：403768件
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地址：2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市 上海市 普陀区
联系人：小陈
联系人电话：0086-021-52280163
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：托吡酯
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：托吡酯
- 价格： ￥118.0/5g ￥378.0/25g
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Topiramate
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：Topiramate
- 价格： ￥729.0/100mg ￥789.0/1g ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：托吡酯
- 价格： ￥34.9/1g ￥29.9/250mg ￥189.9/1ml ￥543.9/100g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$99/10mM*1mLinDMSO