YHO-13351(freebase)
更新时间：2026-01-22 22:53:02
采购访问：21次
| 常用名 | YHO-13351自由基 | CAS号 | 912288-64-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： YHO-13351 (free base) is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.IC50 value:Target: BCRP inhibitorin vitro: YHO-13177 potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 (HCT116/BCRP) cells and SN-38-resistant human lung cancer A549 (A549/SN4) cells that express BCRP, but had little effect in the parental cells. In addition, YHO-13177 potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H460 and NCI-H23, myeloma RPMI-8226, and pancreatic cancer AsPC-1 cells that intrinsically expressed BCRP. YHO-13177 increases the intracellular accumulation of Hoechst 33342, a substrate of BCRP, at 30 minutes and partially suppresses the expression of BCRP protein at more than 24 hours after its treatment in both HCT116/BCRP and A549/SN4 cells [1].in vivo: In mice, YHO-13351 is rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increases the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone has little effect in these tumor models [1]. 物理化学性质： CAS号：912288-64-3 常用中文名：YHO-13351自由基 常用英文名：YHO-13351 free base 分子式：C26H33N3O4S 分子量：483.623 密度：1.2±0.1 g/cm3 沸点：627.1±55.0 °C at 760 mmHg 熔点：N/A 闪点：333.1±31.5 °C 储存条件：2-8℃ |
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- 产品名：YHO-13351 free base
- 价格： ￥1500.9/10mg ￥5000.9/50mg ￥1020.9/5mg ￥8500.9/100mg
- 纯度：99.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$158/10mM*1mLinDMSO