常用名 | AZ876 | CAS号 | 898800-26-5 |
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价格 | 纯度 | 99.0% | |
备货期 | 10天 | 库存 | 现货 |
产品详情(用途,包装等)
用途: AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.(1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling.(2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin.(3) The reference for administration is 20 umol/kg/day in vivo. 物理化学性质: CAS号:898800-26-5 常用中文名:AZ876 常用英文名:AZ876 分子式:C24H29N3O3S 分子量:439.570 密度:1.3±0.1 g/cm3 沸点:605.3±65.0 °C at 760 mmHg 熔点:N/A 闪点:319.9±34.3 °C 储存条件:2-8℃ |