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盐酸莫西普利

更新时间:2024-07-15 12:36:56 采购访问:18次

常用名 盐酸莫昔普利 CAS号 82586-52-5
价格 纯度 98.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. Target: ACEMoexipril is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective [1]. Upon oral administration of moexipril (10 mg/kg/day) to spontaneously hypertensive rats, plasma angiotensin II concentration decreased to undetectable levels, plasma ACE activity was inhibited by 98% and plasma angiotensin I concentration increased 8.6-fold 1 h after dosing. At 24 h, plasma angiotensin I and angiotensin II concentrations had returned to pretreatment levels, whereas plasma ACE activity was still inhibited by 56%. Four-week oral administration of moexipril (0.1-30 mg/kg/day) to spontaneously hypertensive rats lowered blood pressure and differentially inhibited ACE activity in plasma, lung, aorta, heart and kidney in a dose-dependent fashion [2, 3].
物理化学性质:
CAS号:82586-52-5
常用中文名:盐酸莫昔普利
常用英文名:Moexipril HCl
分子式:C27H35ClN2O7
分子量:535.03
密度:N/A
沸点:709.3ºC at 760 mmHg
熔点:141-161ºC
闪点:382.8ºC
储存条件:2-8°C

供应商信息

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参考价格:$55/10mM*1mLinDMSO
其他供应商价格:
2022-02-19 Moexipril HCl
价格:¥512.9
2018-04-11 盐酸莫昔普利
价格:¥需询单
2021-02-06 Moexipril HCl
价格:¥769.0

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