4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺
更新时间：2024-07-15 12:36:56
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| 常用名 | JNJ-17203212 | CAS号 | 821768-06-3 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.IC50 value: 65 nM (human TRPV1), 102 nM (rat TRPV1)Target: TRPVin vivo: JNJ-17203212 reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. Throughout this study, colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle. [1] Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents core hypothermia evoked by sc capsaicin. Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents capsaicin-evoked hypothermia in a dose-response manner. [2] 物理化学性质： CAS号：821768-06-3 常用中文名：JNJ-17203212 常用英文名：JNJ 17203212 分子式：C17H15F6N5O 分子量：419.32400 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
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- 产品名：JNJ 17203212
- 价格： ￥499.9/10mg ￥746.9/25mg ￥1282.9/50mg ￥2201.9/100mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$106/10mM*1mLinDMSO