1-(3,4-二氯苄基)吲哚啉-2,3-二酮
更新时间：2024-07-15 12:36:50
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| 常用名 | MDK83190 | CAS号 | 79183-19-0 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 exerted a cytotoxic effect, reducing the cell numbers by 10–50% and 50–100% in four and eight cell lines, respectively, from the initial levels when tested at 10 μM. At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines, an effect that may be due to nonspecific toxicity. Of the cancer cell lines tested in the panel, cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) were quite sensitive to compound 2-induced killing, with IC50 values ranging from 4 to 9 μM [1]. Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively, also has less inhibition on AChE/BChE with Ki of 48.2/12.6 uM [2]. 物理化学性质： CAS号：79183-19-0 常用中文名：MDK83190 常用英文名：Apoptosis Activator 2 分子式：C15H9Cl2NO2 分子量：306.143 密度：1.5±0.1 g/cm3 沸点：470.6±55.0 °C at 760 mmHg 熔点：N/A 闪点：238.4±31.5 °C 储存条件：Store at RT |
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：1-(3,4-二氯苄基)吲哚啉-2,3-二酮
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮
- 价格： ￥303.9/10mg ￥725.9/50mg ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$66/10mM*1mLinDMSO