1-(4-氯苯甲基)-1H-吲哚-3-甲醛
更新时间：2024-07-15 12:36:41
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| 常用名 | 昂克立新1 | CAS号 | 75629-57-1 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregationof PKCι in nucleus of sensitive cells but not in resistant cells.IC50 value: 1.0 μM(A549, K-ras 12H and p53 Wt) [1]Target: human lung cancer cells with K-Ras mutation; K-Ras/PKCiota pathway inhibitorin vitro: effectively kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations. The cytotoxic effects correlated with apoptosis inductionas was evidenced by increase of apoptotic cells and activation of caspase-3 and caspase-8 upon the treatment of oncrasin-1 in sensitive cells.Treatment with oncrasin-1 also led to abnormal aggregationof PKCι in nucleus of sensitive cells but not in resistant cells. Furthermore, oncrasin-1 induced apoptosis was blocked by siRNA of K-Ras or PKCι suggesting that oncrasin-1 is targeted to a novel K-Ras/PKCι pathway [1]. oncrasin-1 treatment led to coaggregation of PKCiota and splicing factors into megaspliceosomes but had no obvious effects on the DNA repair molecule Rad51. Moreover, oncrasin-1 treatment suppressed the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells but not in resistant cells [2]. in vivo: The in vivo administration of oncrasin-1 suppressed the growth of K-ras mutant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors, without causing detectable toxicity [1]. 物理化学性质： CAS号：75629-57-1 常用中文名：昂克立新1 常用英文名：Oncrasin-1 分子式：C16H12ClNO 分子量：269.72600 密度：1.21g/cm3 沸点：465.5ºC at 760 mmHg 熔点：117 °C 闪点：235.3ºC 储存条件：0-10°C;存放于惰性气体之中;避免空气,加热 |
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：1-(4-氯苯甲基)-1H-吲哚-3-甲醛
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Oncrasin 1
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：昂克立新 1
- 价格： ￥1750.9/100mg ￥285.9/10mg ￥1132.9/50mg ￥3398.9/250mg
- 纯度：95.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$143/10mM*1mLinDMSO