11-羰基-Β-乙酰乳香酸
更新时间：2024-07-15 12:36:17
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| 常用名 | 3-O-乙酰基-11-氧代-β-乳香酸 | CAS号 | 67416-61-9 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Acetyl-11-Keto-β-Boswellic Acid (AKBA) is an active triterpenoid compound from the extract of Boswellia serrate; a novel Nrf2 activator.IC50 value:Target: Nrf2 activatorin vitro: AKBA significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE) [1]. AKBA significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis[3]. AKBA triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes [5].in vivo: AKBA significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon [2]. AKBA administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin [3]. AKBA exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity [4]. 物理化学性质： CAS号：67416-61-9 常用中文名：3-O-乙酰基-11-氧代-β-乳香酸 常用英文名：3-O-Acetyl-11-keto-beta-boswellic acid 分子式：C32H48O5 分子量：512.721 密度：1.1±0.1 g/cm3 沸点：600.3±55.0 °C at 760 mmHg 熔点：N/A 闪点：184.4±25.0 °C 储存条件：−20°C |
上海念兴实业有限公司
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主要合作伙伴：
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Acetyl-11-keto--boswellic acid
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：11-羰基-Β-乙酰乳香酸
- 价格： ￥需询单/100mg ￥需询单/10mg ￥需询单/1g ￥需询单/1mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
- 四川恒诚致远生物科技有限公司
- 四川省 成都市 温江区
- 产品名：3-乙酰基-11-酮基-β-乳香酸
- 价格： ￥需询单/5mg ￥需询单/20mg ￥需询单/100mg ￥需询单/1g
- 纯度：98.0%
- 备货期：需询单
- 联系人：张半夏
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：11-羰基-β-乙酰乳香酸, 乳香
- 价格： ￥529.9/25mg ￥149.9/5mg ￥899.9/1ml ￥1499.9/100mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：￥910/5mg