盐酸甲氟喹
更新时间：2024-07-15 12:35:34
采购访问：32次
| 常用名 | 盐酸甲氟喹 | CAS号 | 51773-92-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine. IC50 Value: 1 microM ( for K+ channel) [1]Target: AntiparasiticMefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. MQ can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS) may be used as a therapeutic modality to kill cancer cells [2].in vitro: Mefloquine inhibitedKvLQT1/minK channel currents with an IC50 value of approximately 1 microM. Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident at lower membrane potentials compared with higher ones. HERG channel currents were about 6-fold less sensitive to block by mefloquine (IC50 = 5.6 microM). Block of HERG displayed a positive voltage dependence with maximal inhibition obtained at more depolarized potentials [1]. MQ has a highly selective cytotoxicity that inhibits PCa cell growth. MQ-mediated ROS simultaneously downregulated Akt phosphorylation and activated extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and adenosine monophosphate-activated protein kinase (AMPK) signaling in PC3 cells [2]. in vivo: Pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9-11 post coitum (pc). The dams were euthanized on day 12 pc and gestational and embryos histological parameters were evaluated [3].Clinical trial: Activity of Mefloquine Against Urinary Schistosomiasis . Phase 2 物理化学性质： CAS号：51773-92-3 常用中文名：盐酸甲氟喹 常用英文名：Mefloquine hydrochloride 分子式：C17H17ClF6N2O 分子量：378.312 密度：1.4±0.1 g/cm3 沸点：415.7±40.0 °C at 760 mmHg 熔点：250-254ºC 闪点：205.2±27.3 °C 储存条件：Refrigerator |
上海念兴实业有限公司
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：盐酸甲氟喹
- 价格： ￥392.9/1g ￥160.9/250mg ￥205.9/1ml ￥1608.9/5g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：盐酸甲氟喹
- 价格： ￥需询单/100mg ￥需询单/1g ￥需询单/250mg ￥需询单/5g
- 纯度：99.0%
- 备货期：需询单
- 联系人：王汐瑶
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参考价格：￥152/250mg