N,N-二甲基-2-(苯基(邻甲苯基)甲氧基)乙胺2-羟基丙-1,2,3-三羧酸盐
更新时间：2024-07-15 12:35:23
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| 常用名 | 枸櫞酸奧芬那君 | CAS号 | 4682-36-4 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.Target: NMDA ReceptorOrphenadrine has been used as an antiparkinsonian, antispastic and analgesic drug. Orphenadrine inhibits [3H]MK-801 binding to the phencyclidine (PCP) binding site of the N-methyl-D-aspartate (NMDA)-receptor in homogenates of postmortem human frontal cortex with a Ki-value of 6.0 +/- 0.7 microM. The NMDA receptor antagonistic effects of orphenadrine were assessed using concentration- and patch-clamp techniques on cultured superior colliculus neurones. Orphenadrine blocked open NMDA receptor channels with fast kinetics and in a strongly voltage-dependent manner. The IC50-value against steady state currents at -70 mV was 16.2 +/- 1.6 microM (n = 6). Orphenadrine exhibited relatively fast, concentration-dependent open channel blocking kinetics (Kon 0.013 +/- 0.002 10(6) M-1S-1) whereas the offset rate was concentration-independent (Koff 0.230 +/- 0.004 S-1) [1]. Orphenadrine competitively inhibited [3H]nisoxetine binding in rat vas deferens membranes (Ki = 1.05+/-0.20 microM). It can be concluded that orphenadrine, at low micromolar concentrations, interacts with the noradrenaline reuptake system inhibiting its functionality and thus potentiating the effect of noradrenaline [2]. 物理化学性质： CAS号：4682-36-4 常用中文名：枸櫞酸奧芬那君 常用英文名：orphenadrine citrate 分子式：C24H31NO8 分子量：461.50500 密度：1.014 g/cm3 沸点：363ºC at 760 mmHg 熔点：132-134ºC 闪点：107.1ºC 储存条件：2-8°C |
上海念兴实业有限公司
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- 产品名：Orphenadrine Citrate
- 价格： ￥329.9/5g ￥178.9/1ml ￥1338.9/25g ￥需询单/1g
- 纯度：95.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$66/10mM*1mLinDMSO