1'-(4-(1-(4-氟苯基)-1H-吲哚-3-基)丁基)-3H-螺环[异苯并呋喃-1,4'-哌啶]盐酸盐
更新时间：2024-07-15 12:33:52
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| 常用名 | 西拉美新盐酸盐 | CAS号 | 224177-60-0 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Siramesine(Lu 28-179) Hcl is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. IC50 value:Target: sigma-2 receptor; lysosome-destabilizing agentsiramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost [1]. Siramesine, a sigma-2 receptor agonist originally developed as an anti-depressant, can induce cell death in transformed cells through a mechanism involving lysosomal destabilization [2].in vivo: SA4503 or siramesine given jointly with MEM (as well as with AMA) decreased the immobility time in rats. The effect of SA4503 and AMA co-administration was antagonized by progesterone, a sigma1 receptor antagonistic neurosteroid. Combined treatment with siramesine and AMA was modified by neither progesterone nor BD1047 (a novel sigma antagonist with preferential affinity for sigma1 sites) [3] 物理化学性质： CAS号：224177-60-0 常用中文名：西拉美新盐酸盐 常用英文名：Siramesine (hydrochloride) 分子式：C30H32ClFN2O 分子量：491.039 密度：N/A 沸点：N/A 熔点：225 °C 闪点：N/A 储存条件：-20℃，干燥，密封 |
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：西拉美新盐酸盐
- 价格： ￥720.9/1ml ￥2999.9/100mg ￥1099.9/25mg ￥349.9/5mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：1'-(4-(1-(4-氟苯基)-1H-吲哚-3-基)丁基)-3H-螺环[异苯并呋喃-1,4'-哌啶]盐酸盐
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$330/10mM*1mLinDMSO