(2R,4S)-N-[1-[3,5-双(三氟甲基)苯甲酰]-2-(4-氯苄基)哌啶-4-基]喹啉-4
更新时间：2024-07-15 12:32:55
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| 常用名 | (R)-(+)-2-氨基-4-羟基丁酸 | CAS号 | 177707-12-9 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. IC50 value: 2.6 nMTarget: NK-1 receptorIn vitro, the binding of NKP608 to bovine retina was characterized by an IC50 of 2.6+/-0.4 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC(50) values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13+/-2 and 27+/-2 nM in gerbil midbrain and rat striatum, respectively. In vivo, using the hind foot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID(50)=0.23 mg/kg; 2 h pretreatment), supporting a central activity of NKP608. NKP608 may prove a useful anxiolytic compound. 物理化学性质： CAS号：177707-12-9 常用中文名：(R)-(+)-2-氨基-4-羟基丁酸 常用英文名：NKP608 分子式：C31H24ClF6N3O2 分子量：619.985 密度：1.4±0.1 g/cm3 沸点：719.2±60.0 °C at 760 mmHg 熔点：N/A 闪点：388.8±32.9 °C 储存条件：2-8℃ |
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- 产品名：NKP608
- 价格： ￥1741.0/5mg ￥14731.0/10mg ￥需询单/1g ￥需询单/1g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$432/10mM*1mLinDMSO