ML314
更新时间：2024-07-15 12:32:12
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| 常用名 | ML314 | CAS号 | 1448895-09-7 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.IC50 value: 1.9 uM (EC50) [1]Target: NTR1 agonistMedicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway. Signaling mediated by β-arrestin has distinct biochemical and functional consequences that may lead to physiological advantages as described below. This probe report describes the discovery and properties of ML301 and summarizes the HTS and follow-up campaign, which identified ML314. 物理化学性质： CAS号：1448895-09-7 常用中文名：ML314 常用英文名：ML314 分子式：C24H28N4O3 分子量：420.504 密度：1.2±0.1 g/cm3 沸点：496.1±45.0 °C at 760 mmHg 熔点：N/A 闪点：253.8±28.7 °C 储存条件：2-8℃ |
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- 产品名：ML314
- 价格： ￥2300.9/10mg ￥5100.9/25mg ￥750.9/2mg ￥1350.9/5mg
- 纯度：99.0%
- 备货期：10天
- 联系人：阿拉丁
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参考价格：$158/10mM*1mLinDMSO