PIM447
更新时间：2024-07-15 12:30:39
采购访问：2次
| 常用名 | PIM447 | CAS号 | 1210608-43-7 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.target: pan-PIM inhibitor [2] [3]In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.[1]In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma.[1] 物理化学性质： CAS号：1210608-43-7 常用中文名：PIM447 常用英文名：PIM447 分子式：C24H23F3N4O 分子量：440.461 密度：1.3±0.1 g/cm3 沸点：493.7±45.0 °C at 760 mmHg 熔点：N/A 闪点：252.4±28.7 °C 储存条件：-20℃ |
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