PIM447

• 常用名: PIM447
• 英文名: PIM447
• CAS号: 1210608-43-7
• 分子量: 440.461
• 密度: 1.3±0.1 g/cm3
• 沸点: 493.7±45.0 °C at 760 mmHg
• 分子式: C₂₄H₂₃F₃N₄O
• 熔点: N/A
• 闪点: 252.4±28.7 °C

PIM447用途

PIM447是一个新颖的pan-PIM抑制剂。

PIM447名称

• 中文名: PIM447
• 英文名: PIM447

PIM447生物活性

• 描述: PIM447是一个新颖的pan-PIM抑制剂。
• 相关类别:
  信号通路 >> JAK/STAT信号通路 >> 皮姆
  研究领域 >> 癌症
• 参考文献:

  [1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.

  [2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor

  [3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447. Oncotarget. 2016 Aug 20

PIM447物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 493.7±45.0 °C at 760 mmHg
• 分子式: C₂₄H₂₃F₃N₄O
• 分子量: 440.461
• 闪点: 252.4±28.7 °C
• 精确质量: 440.182404
• LogP: 5.20
• 外观性状: 粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.593
• 储存条件: -20℃

PIM447英文别名

• 9TG5O4V25H
• N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide
• 2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-
• N-{4-[(1r,3s,5s)-3-Amino-5-Methylcyclohexyl]pyridin-3-Yl}-6-(2,6-Difluorophenyl)-5-Fluoropyridine-2-Carboxamide