常用名 | 羟基积雪草苷 | CAS号 | 34540-22-2 |
---|---|---|---|
价格 | ¥需询单/1kg ¥需询单/1g | 纯度 | 98.0% |
备货期 | 3天 | 库存 | 现货 |
产品详情(用途,包装等)
用途: Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.), as an anti-inflammatory, anti-oxidative activities and anti-aging agent. [1]In vitro: Madecassoside exhibit significant anti-proliferative and anti-invasive effect in HGF-induced HepG2 and SMMC-77 cells. Madecassoside inhibit the HGF-induced activation of cMET-PKC-ERK1/2-COX-2-PGE2cascade. [1]In vivo: Administration of madecassoside, p.o. , exhibit a direct anti-PF effect in mice. Madecassoside increase the expression of hepatocyte growth factor (HGF) in colon tissues, and HGF receptor antagonists attenuated its anti-PF effect. madecassoside in mice are not mediated by its metabolites or itself after absorption into blood. Instead, madecassoside increases the activity of PPAR-γ, which subsequently increases HGF expression in colonic epithelial cells. [2] The reference for administration is 12 mg/kg. [3] 物理化学性质: CAS号:34540-22-2 常用中文名:羟基积雪草苷 常用英文名:Madecassoside 分子式:C48H78O20 分子量:975.121 密度:1.5±0.1 g/cm3 沸点:1043.6±65.0 °C at 760 mmHg 熔点:N/A 闪点:295.8±27.8 °C 储存条件:2-8°C |