AZD5582
更新时间：2023-10-18 15:34:26
| 常用名 | AZD5582 | CAS号 | 1258392-53-8 |
|---|---|---|---|
| 价格 | ￥需询单/1g ￥需询单/1mg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). IC50 value: 15/21/15 nM (cIAP1/cIAP2/XIAP) [1]Target: IAPs inhibitorAZD5582 causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro. When administered intravenously to MDA-MB-231 xenograft-bearing mice, AZD5582 results in cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions following two weekly doses of 3.0 mg/kg. Antiproliferative effects are observed with AZD5582 in only a small subset of the over 200 cancer cell lines examined, consistent with other published IAP inhibitors [1]. AZD5582 significantly enhanced apoptosis induced by the death receptor (DR) agonist tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Importantly, killing by TRAIL plus AZD5582 was independent of adverse prognostic features including TP53 deletion which is strongly associated with chemoresistance in CLL [2]. 物理化学性质： CAS号：1258392-53-8 常用中文名：AZD5582 常用英文名：AZD5582 分子式：C58H78N8O8 分子量：1015.289 密度：1.3±0.1 g/cm3 沸点：1207.3±65.0 °C at 760 mmHg 熔点：N/A 闪点：683.9±34.3 °C 储存条件：2-8℃ |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：AZD5582
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：AZD5582
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：AZD5582
- 价格： ￥1799.9/10mg ￥999.9/5mg ￥需询单/1g ￥需询单/10g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$174/10mM*1mLinDMSO